Mfn2 Affects Embryo Development via Mitochondrial Dysfunction and Apoptosis

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چکیده

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Mfn2 Affects Embryo Development via Mitochondrial Dysfunction and Apoptosis

BACKGROUND Growth factors, energy sources, and mitochondrial function strongly affect embryo growth and development in vitro. The biological role and prospective significance of the mitofusin gene Mfn2 in the development of preimplantation embryos remain poorly understood. Our goal is to profile the role of Mfn2 in mouse embryos and determine the underlying mechanism of Mfn2 function in embryo ...

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2015

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0125680